Many people mistakenly think Depo-Provera is just another contraceptive like the pill. However, Depo-Provera is, in fact, very different from taking the pill. The hormones of the pill are out of your body within days of stopping your pills. (That is why you have to throw out your pack and start a new one if you miss several consecutive days of taking them.) On the other hand, Depo-Provera works by continuously releasing hormones into your body. A single injection typically works for three months or longer.
It?s been my experience that the majority of women who have been on Depo-Provera take anywhere from 9 to 12 months to get all the hormones out of their bodies, start ovulating, and become pregnant. This is nothing to be terribly concerned about, but is one reason why I steer patients who may want to become pregnant soon away from choosing Depo-Provera for contraception.
Source: http://www.fertibella.com/get-pregnant/how-to-get-pregnant-fast.php#comment-4293
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